Knockdown of TRIM5α or TRIM11 increases lentiviral vector transduction efficiency of human Muller cells.
Mar 01 2021
PubMed ID: 33440192 Author(s): Sauter MM, Brandt CR. Knockdown of TRIM5α or TRIM11 increases lentiviral vector transduction efficiency of human Muller cells. Exp Eye Res. 2021 Mar;204:108436. doi: 10.1016/j.exer.2021.108436. Epub 2021 Jan 10. PMID 33440192…
Read MoreGenomic nucleotide-based distance analysis for delimiting old world monkey derived herpes simplex virus species.
Jun 28 2020
PubMed ID: 32590937 Author(s): Kolb AW, Brandt CR. Genomic nucleotide-based distance analysis for delimiting old world monkey derived herpes simplex virus species. BMC Genomics. 2020 Jun 26;21(1):436. doi: 10.1186/s12864-020-06847-w. PMID 32590937 Journal: Bmc Genomics, Volume…
Read MoreCorrection: Using HSV-1 Genome Phylogenetics to Track Past Human Migrations.
May 31 2019
PubMed ID: 31145764 Author(s): Kolb AW, Ané C, Brandt CR. Correction: Using HSV-1 Genome Phylogenetics to Track Past Human Migrations. PLoS One. 2019 May 30;14(5):e0217890. doi: 10.1371/journal.pone.0217890. eCollection 2019. Journal: Plo S One, Volume 14,…
Read MoreoGVHD
Jan 28 2019
Scleral Contact Lens Reduction of Dry Eye Inflammation in Patients with Graft-Versus-Host Disease (GVHD)
Read MoreToll-like receptors 4, 5, 6 and 7 are constitutively expressed in non-human primate retinal neurons.
Jun 30 2018
PubMed ID: 29954626 Author(s): Sauter MM, Kolb AW, Brandt CR. Toll-like receptors 4, 5, 6 and 7 are constitutively expressed in non-human primate retinal neurons. J Neuroimmunol. 2018 Sep 15;322:26-35. doi: 10.1016/j.jneuroim.2018.06.007. Epub 2018 Jun…
Read MoreGenomic, Recombinational and Phylogenetic Characterization of Global Feline Herpesvirus 1 Isolates.
Apr 02 2018
PubMed ID: 29605685 Author(s): Lewin AC, Kolb AW, McLellan GJ, Bentley E, Bernard KA, Newbury SP, Brandt CR. Genomic, Recombinational and Phylogenetic Characterization of Global Feline Herpesvirus 1 Isolates. Virology. 2018 May;518:385-397. doi: 10.1016/j.virol.2018.03.018. Epub…
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Improving Glaucoma Treatment // Experimental Gene Transfer Techniques
Feb 14 2018
Listen to Full Interview In an interview with WYPL-FM’s (Memphis, TN) radio show Eye on Vision, Curtis Brandt, PhD, professor of ophthalmology and visual sciences, discussed the research of experimental gene transfer techniques to…
Read MoreProteasome Inhibition Increases the Efficiency of Lentiviral Vector-Mediated Transduction of Trabecular Meshwork.
Jan 18 2018
PubMed ID: 29340644 Author(s): Aktas Z, Rao H, Slauson SR, Gabelt BT, Larsen IV, Sheridan RTC, Herrnberger L, Tamm ER, Kaufman PL, Brandt CR. Proteasome Inhibition Increases the Efficiency of Lentiviral Vector-Mediated Transduction of Trabecular…
Read MorePhylogenetic and recombination analysis of the herpesvirus genus varicellovirus.
Nov 22 2017
PubMed ID: 29157201 Author(s): Kolb AW, Lewin AC, Moeller Trane R, McLellan GJ, Brandt CR. Phylogenetic and recombination analysis of the herpesvirus genus varicellovirus. BMC Genomics. 2017 Nov 21;18(1):887. doi: 10.1186/s12864-017-4283-4. Journal: Bmc Genomics, Volume…
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Department Labs Explore Gene Delivery for Treating Glaucoma
Jan 17 2017
January is National Glaucoma Awareness Month Glaucoma is the second leading cause of blindness in the US and is usually associated with increased pressure in the eye. This causes insults to nerve cells (retinal ganglion…
Read MoreEffect of a Soluble Epoxide Hydrolase Inhibitor, UC1728, on LPS-Induced Uveitis in the Rabbit.
Jan 10 2017
PubMed ID: 28066796 Author(s): McLellan GJ, Aktas Z, Hennes-Beean E, Kolb AW, Larsen IV, Schmitz EJ, Clausius HR, Yang J, Hwang SH, Morisseau C, Inceoglu B, Hammock BD, Brandt CR. Effect of a Soluble Epoxide…
Read MoreA Mouse Model of Multi-Drug Resistant Staphylococcus aureus-induced Ocular Disease.
Nov 30 2016
PubMed ID: 27896297 Author(s): Broekema NM, Larsen IV, Naruzawa ES, Filutowicz M, Kolb AW, Teixeira LB, Brandt CR. A Mouse Model of Multi-Drug Resistant Staphylococcus aureus-induced Ocular Disease. J Ocul Biol. 2016 Nov;4(2). doi: 10.13188/2334-2838.1000026.…
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LEBW Gift of Sight Discovery Fund Advances Glaucoma Research at UW-Madison
Nov 07 2016
Glaucoma is the second leading cause of blindness in the world, according to the World Health Organization. The University of Wisconsin Department of Ophthalmology and Visual Sciences has a long history of focused study and…
Read MoreMapping Murine Corneal Neovascularization and Weight Loss Virulence Determinants in the Herpes Simplex Virus 1 Genome and the Detection of an Epistatic Interaction between the UL and IRS/US Regions.
Jul 08 2016
PubMed ID: 27384650 Author(s): Lee K, Kolb AW, Larsen I, Craven M, Brandt CR. Mapping Murine Corneal Neovascularization and Weight Loss Virulence Determinants in the Herpes Simplex Virus 1 Genome and the Detection of an…
Read MorePrimate neural retina upregulates IL-6 and IL-10 in response to a herpes simplex vector suggesting the presence of a pro-/anti-inflammatory axis.
May 14 2016
PubMed ID: 27170050 Author(s): Sauter MM, Brandt CR. Primate neural retina upregulates IL-6 and IL-10 in response to a herpes simplex vector suggesting the presence of a pro-/anti-inflammatory axis. Exp Eye Res. 2016 Jul;148:12-23. doi:…
Read MoreBoth CD8+ and CD4+ T Cells Contribute to Corneal Clouding and Viral Clearance following Vaccinia Virus Infection in C57BL/6 Mice.
May 14 2016
PubMed ID: 27170749 Author(s): Larsen IV, Clausius H, Kolb AW, Brandt CR. Both CD8+ and CD4+ T Cells Contribute to Corneal Clouding and Viral Clearance following Vaccinia Virus Infection in C57BL/6 Mice. J Virol. 2016…
Read MoreQuantitative Trait Locus Based Virulence Determinant Mapping of the HSV-1 Genome in Murine Ocular Infection: Genes Involved in Viral Regulatory and Innate Immune Networks Contribute to Virulence.
Mar 11 2016
PubMed ID: 26962864 Author(s): Kolb AW, Lee K, Larsen I, Craven M, Brandt CR. Quantitative Trait Locus Based Virulence Determinant Mapping of the HSV-1 Genome in Murine Ocular Infection: Genes Involved in Viral Regulatory and…
Read MoreRecombination Analysis of Herpes Simplex Virus 1 Reveals a Bias toward GC Content and the Inverted Repeat Regions.
May 01 2015
PubMed ID: 25926637 Author(s): Lee K, Kolb AW, Sverchkov Y, Cuellar JA, Craven M, Brandt CR. Recombination Analysis of Herpes Simplex Virus 1 Reveals a Bias toward GC Content and the Inverted Repeat Regions. J…
Read MoreGenomic, phylogenetic, and recombinational characterization of herpes simplex virus 2 strains.
Apr 10 2015
PubMed ID: 25855744 Author(s): Kolb AW, Larsen IV, Cuellar JA, Brandt CR. Genomic, phylogenetic, and recombinational characterization of herpes simplex virus 2 strains. J Virol. 2015 Jun;89(12):6427-34. doi: 10.1128/JVI.00416-15. Epub 2015 Apr 8. Journal: Journal…
Read MoreViral Vector Effects on Exoenzyme C3 Transferase-Mediated Actin Disruption and on Outflow Facility.
Mar 19 2015
PubMed ID: 25783606 Author(s): Slauson SR, Peters DM, Schwinn MK, Kaufman PL, Gabelt BT, Brandt CR. Viral Vector Effects on Exoenzyme C3 Transferase-Mediated Actin Disruption and on Outflow Facility. Invest Ophthalmol Vis Sci. 2015 Apr;56(4):2431-8.…
Read MorePeptide therapeutics for treating ocular surface infections.
Sep 25 2014
PubMed ID: 25250986 Author(s): Brandt CR. Peptide therapeutics for treating ocular surface infections. J Ocul Pharmacol Ther. 2014 Nov;30(9):691-9. doi: 10.1089/jop.2014.0089. Epub 2014 Sep 24. Review. Journal: Journal Of Ocular Pharmacology And Therapeutics : The…
Read MoreOligonucleotides designed to inhibit TLR9 block Herpes simplex virus type 1 infection at multiple steps.
Jul 06 2014
PubMed ID: 24995383 Author(s): Sauter MM, Gauger JJ, Brandt CR. Oligonucleotides designed to inhibit TLR9 block Herpes simplex virus type 1 infection at multiple steps. Antiviral Res. 2014 Sep;109:83-96. doi: 10.1016/j.antiviral.2014.06.015. Epub 2014 Jul 1.…
Read MoreProspects for lentiviral vector mediated prostaglandin F synthase gene delivery in monkey eyes in vivo.
Feb 25 2014
PubMed ID: 24559478 Author(s): Lee ES, Rasmussen CA, Filla MS, Slauson SR, Kolb AW, Peters DM, Kaufman PL, Gabelt BT, Brandt CR. Prospects for lentiviral vector mediated prostaglandin F synthase gene delivery in monkey eyes…
Read MoreUsing HSV-1 genome phylogenetics to track past human migrations.
Oct 23 2013
PubMed ID: 24146849 Author(s): Kolb AW, Ané C, Brandt CR. Using HSV-1 genome phylogenetics to track past human migrations. PLoS One. 2013 Oct 16;8(10):e76267. doi: 10.1371/journal.pone.0076267. eCollection 2013. Erratum in: PLoS One. 2019 May 30;14(5):e0217890.…
Read MoreCharacterization and cytotoxic activity of sulfated derivatives of polysaccharides from Agaricus brasiliensis.
Mar 21 2013
PubMed ID: 23511057 Author(s): Cardozo FT, Camelini CM, Cordeiro MN, Mascarello A, Malagoli BG, Larsen IV, Rossi MJ, Nunes RJ, Braga FC, Brandt CR, Simões CM. Characterization and cytotoxic activity of sulfated derivatives of polysaccharides…
Read MoreIn vivo anti-herpes simplex virus activity of a sulfated derivative of Agaricus brasiliensis mycelial polysaccharide.
Mar 20 2013
PubMed ID: 23507287 Author(s): Cardozo FT, Larsen IV, Carballo EV, Jose G, Stern RA, Brummel RC, Camelini CM, Rossi MJ, Simões CM, Brandt CR. In vivo anti-herpes simplex virus activity of a sulfated derivative of…
Read MoreA cationic peptide, TAT-Cd°, inhibits herpes simplex virus type 1 ocular infection in vivo.
Jan 24 2013
PubMed ID: 23341013 Author(s): Jose GG, Larsen IV, Gauger J, Carballo E, Stern R, Brummel R, Brandt CR. A cationic peptide, TAT-Cd°, inhibits herpes simplex virus type 1 ocular infection in vivo. Invest Ophthalmol Vis…
Read MoreAntiviral activity of the EB peptide against zoonotic poxviruses.
Jan 10 2012
PubMed ID: 22225618 Author(s): Altmann SE, Brandt CR, Jahrling PB, Blaney JE. Antiviral activity of the EB peptide against zoonotic poxviruses. Virol J. 2012 Jan 6;9:6. doi: 10.1186/1743-422X-9-6. Journal: Virology Journal, Volume 9, Jan 2012…
Read MoreOcular distribution, spectrum of activity, and in vivo viral neutralization of a fully humanized anti-herpes simplex virus IgG Fab fragment following topical application.
Dec 29 2011
PubMed ID: 22203590 Author(s): Berdugo M, Larsen IV, Abadie C, Deloche C, Kowalczuk L, Touchard E, Dubielzig R, Brandt CR, Behar-Cohen F, Combette JM. Ocular distribution, spectrum of activity, and in vivo viral neutralization of…
Read MoreMultiplex sequencing of seven ocular herpes simplex virus type-1 genomes: phylogeny, sequence variability, and SNP distribution.
Oct 22 2011
PubMed ID: 22016062 Author(s): Kolb AW, Adams M, Cabot EL, Craven M, Brandt CR. Multiplex sequencing of seven ocular herpes simplex virus type-1 genomes: phylogeny, sequence variability, and SNP distribution. Invest Ophthalmol Vis Sci. 2011…
Read MoreVirus aggregating peptide enhances the cell-mediated response to influenza virus vaccine.
Aug 16 2011
PubMed ID: 21839131 Author(s): Jones JC, Settles EW, Brandt CR, Schultz-Cherry S. Virus aggregating peptide enhances the cell-mediated response to influenza virus vaccine. Vaccine. 2011 Oct 13;29(44):7696-703. doi: 10.1016/j.vaccine.2011.07.133. Epub 2011 Aug 10. Journal: Vaccine,…
Read MoreSequence variation in the herpes simplex virus U(S)1 ocular virulence determinant.
Apr 27 2011
PubMed ID: 21519032 Author(s): Kolb AW, Schmidt TR, Dyer DW, Brandt CR. Sequence variation in the herpes simplex virus U(S)1 ocular virulence determinant. Invest Ophthalmol Vis Sci. 2011 Jun 28;52(7):4630-8. doi: 10.1167/iovs.10-7032. Journal: Investigative Ophthalmology…
Read MoreIdentification of the minimal active sequence of an anti-influenza virus peptide.
Apr 01 2011
PubMed ID: 21220525 Author(s): Jones JC, Settles EW, Brandt CR, Schultz-Cherry S. Identification of the minimal active sequence of an anti-influenza virus peptide. Antimicrob Agents Chemother. 2011 Apr;55(4):1810-3. doi: 10.1128/AAC.01428-10. Epub 2011 Jan 10. PMID…
Read MoreEvaluation of therapeutic interventions for vaccinia virus keratitis.
Mar 01 2011
PubMed ID: 21278209 Author(s): Altmann S, Brandt CR, Murphy CJ, Patnaikuni R, Takla T, Toomey M, Nesbit B, McIntyre K, Covert J, Dubielzig R, Leatherberry G, Adkins E, Kodihalli S. Evaluation of therapeutic interventions for…
Read MoreA cationic TAT peptide inhibits Herpes simplex virus type 1 infection of human corneal epithelial cells.
Dec 01 2010
PubMed ID: 21029018 Author(s): Larsen IV, Brandt CR. A cationic TAT peptide inhibits Herpes simplex virus type 1 infection of human corneal epithelial cells. J Ocul Pharmacol Ther. 2010 Dec;26(6):541-7. doi: 10.1089/jop.2010.0076. Epub 2010 Oct…
Read MoreThe virucidal EB peptide protects host cells from herpes simplex virus type 1 infection in the presence of serum albumin and aggregates proteins in a detergent-like manner.
Oct 01 2010
PubMed ID: 20643896 Author(s): Bultmann H, Girdaukas G, Kwon GS, Brandt CR. The virucidal EB peptide protects host cells from herpes simplex virus type 1 infection in the presence of serum albumin and aggregates proteins…
Read MoreKinetics of immune cell infiltration in vaccinia virus keratitis.
Apr 09 2010
PubMed ID: 20375330 Author(s): Altmann S, Toomey M, Nesbit B, McIntyre K, Covert J, Dubielzig RR, Leatherberry G, Adkins E, Murphy CJ, Brandt CR. Kinetics of immune cell infiltration in vaccinia virus keratitis. Invest Ophthalmol…
Read MoreA quantitative rabbit model of vaccinia keratitis.
Apr 09 2010
PubMed ID: 20375331 Author(s): Altmann S, Emanuel A, Toomey M, McIntyre K, Covert J, Dubielzig RR, Leatherberry G, Murphy CJ, Kodihalli S, Brandt CR. A quantitative rabbit model of vaccinia keratitis. Invest Ophthalmol Vis Sci.…
Read MoreCOCH transgene expression in cultured human trabecular meshwork cells and its effect on outflow facility in monkey organ cultured anterior segments.
Nov 26 2009
PubMed ID: 19933177 Author(s): Lee ES, Gabelt BT, Faralli JA, Peters DM, Brandt CR, Kaufman PL, Bhattacharya SK. COCH transgene expression in cultured human trabecular meshwork cells and its effect on outflow facility in monkey…
Read MoreGene therapy targeting glaucoma: where are we?
Jun 23 2009
PubMed ID: 19539835 Author(s): Liu X, Rasmussen CA, Gabelt BT, Brandt CR, Kaufman PL. Gene therapy targeting glaucoma: where are we? Surv Ophthalmol. 2009 Jul-Aug;54(4):472-86. doi: 10.1016/j.survophthal.2009.04.003. Review. Journal: Survey Of Ophthalmology, Volume 54, Issue…
Read MoreInhibition of Vaccinia virus entry by a broad spectrum antiviral peptide.
Jun 05 2009
PubMed ID: 19395056 Author(s): Altmann SE, Jones JC, Schultz-Cherry S, Brandt CR. Inhibition of Vaccinia virus entry by a broad spectrum antiviral peptide. Virology. 2009 Jun 5;388(2):248-59. doi: 10.1016/j.virol.2009.03.023. Epub 2009 Apr 22. PMID 19395056…
Read MoreMultiple peptides homologous to herpes simplex virus type 1 glycoprotein B inhibit viral infection.
Dec 24 2008
PubMed ID: 19104014 Author(s): Akkarawongsa R, Pocaro NE, Case G, Kolb AW, Brandt CR. Multiple peptides homologous to herpes simplex virus type 1 glycoprotein B inhibit viral infection. Antimicrob Agents Chemother. 2009 Mar;53(3):987-96. doi: 10.1128/AAC.00793-08.…
Read MoreH-1152 effects on intraocular pressure and trabecular meshwork morphology of rat eyes.
Jul 31 2008
PubMed ID: 18665808 Author(s): Yu M, Chen X, Wang N, Cai S, Li N, Qiu J, Brandt CR, Kaufman PL, Liu X. H-1152 effects on intraocular pressure and trabecular meshwork morphology of rat eyes. J…
Read MoreInhibition of herpes simplex virus type 1 infection by cationic beta-peptides.
Jun 01 2008
PubMed ID: 18391029 Author(s): Akkarawongsa R, Potocky TB, English EP, Gellman SH, Brandt CR. Inhibition of herpes simplex virus type 1 infection by cationic beta-peptides. Antimicrob Agents Chemother. 2008 Jun;52(6):2120-9. doi: 10.1128/AAC.01424-07. Epub 2008 Apr…
Read MoreInduction of interleukin-6 in human retinal epithelial cells by an attenuated Herpes simplex virus vector requires viral replication and NFkappaB activation.
Feb 01 2008
PubMed ID: 18061164 Author(s): Cai S, Brandt CR. Induction of interleukin-6 in human retinal epithelial cells by an attenuated Herpes simplex virus vector requires viral replication and NFkappaB activation. Exp Eye Res. 2008 Feb;86(2):178-88. Epub…
Read MoreEvaluation of a theta-defensin in a Murine model of herpes simplex virus type 1 keratitis.
Nov 01 2007
PubMed ID: 17962464 Author(s): Brandt CR, Akkarawongsa R, Altmann S, Jose G, Kolb AW, Waring AJ, Lehrer RI. Evaluation of a theta-defensin in a Murine model of herpes simplex virus type 1 keratitis. Invest Ophthalmol…
Read MoreOcular drug delivery: molecules, cells, and genes.
Jun 01 2007
PubMed ID: 17508043 Author(s): Liu X, Brandt CR, Rasmussen CA, Kaufman PL. Ocular drug delivery: molecules, cells, and genes. Can J Ophthalmol. 2007 Jun;42(3):447-54. Review. PMID 17508043 Journal: Canadian Journal Of Ophthalmology. Journal Canadien D’ophtalmologie,…
Read MoreSialic acid on herpes simplex virus type 1 envelope glycoproteins is required for efficient infection of cells.
Apr 01 2007
PubMed ID: 17229687 Author(s): Teuton JR, Brandt CR. Sialic acid on herpes simplex virus type 1 envelope glycoproteins is required for efficient infection of cells. J Virol. 2007 Apr;81(8):3731-9. Epub 2007 Jan 17. PMID 17229687…
Read MoreAddition of a C-terminal cysteine improves the anti-herpes simplex virus activity of a peptide containing the human immunodeficiency virus type 1 TAT protein transduction domain.
Jan 31 2007
PubMed ID: 17261627 Author(s): Bultmann H, Teuton J, Brandt CR. Addition of a C-terminal cysteine improves the anti-herpes simplex virus activity of a peptide containing the human immunodeficiency virus type 1 TAT protein transduction domain.…
Read MoreInhibition of influenza virus infection by a novel antiviral peptide that targets viral attachment to cells.
Dec 01 2006
PubMed ID: 17005658 Author(s): Jones JC, Turpin EA, Bultmann H, Brandt CR, Schultz-Cherry S. Inhibition of influenza virus infection by a novel antiviral peptide that targets viral attachment to cells. J Virol. 2006 Dec;80(24):11960-7. Epub…
Read MoreCorneal toxicity of cell-penetrating peptides that inhibit Herpes simplex virus entry.
Aug 01 2006
PubMed ID: 16910869 Author(s): Akkarawongsa R, Cullinan AE, Zinkel A, Clarin J, Brandt CR. Corneal toxicity of cell-penetrating peptides that inhibit Herpes simplex virus entry. J Ocul Pharmacol Ther. 2006 Aug;22(4):279-89. PMID 16910869 Journal: Journal…
Read MoreThe effect of C3 transgene expression on actin and cellular adhesions in cultured human trabecular meshwork cells and on outflow facility in organ cultured monkey eyes.
Dec 13 2005
PubMed ID: 16379023 Author(s): Liu X, Hu Y, Filla MS, Gabelt BT, Peters DM, Brandt CR, Kaufman PL. The effect of C3 transgene expression on actin and cellular adhesions in cultured human trabecular meshwork cells…
Read MoreThe role of viral and host genes in corneal infection with herpes simplex virus type 1.
May 01 2005
PubMed ID: 15862167 Author(s): Brandt CR. The role of viral and host genes in corneal infection with herpes simplex virus type 1. Exp Eye Res. 2005 May;80(5):607-21. Review. PMID 15862167 Journal: Experimental Eye Research, Volume…
Read MoreEvaluation of the antitumor effects of Herpes simplex virus lacking ribonucleotide reductase in a murine retinoblastoma model.
Oct 30 2004
PubMed ID: 15512963 Author(s): Cullinan AE, Lindstrom MJ, Sabet S, Albert DM, Brandt CR. Evaluation of the antitumor effects of Herpes simplex virus lacking ribonucleotide reductase in a murine retinoblastoma model. Curr Eye Res. 2004…
Read MoreVirulence genes in herpes simplex virus type 1 corneal infection.
Aug 01 2004
PubMed ID: 15512957 Author(s): Brandt CR. Virulence genes in herpes simplex virus type 1 corneal infection. Curr Eye Res. 2004 Aug-Sep;29(2-3):103-17. Review. PMID 15512957 Journal: Current Eye Research, Volume 29, Issue 2 3,
Read MoreCytokine induced apoptosis in human retinoblastoma cells.
Apr 22 2004
PubMed ID: 15133451 Author(s): Cullinan AE, Brandt CR. Cytokine induced apoptosis in human retinoblastoma cells. Mol Vis. 2004 Apr 22;10:315-22. PMID 15133451 Journal: Molecular Vision, Volume 10, Apr 2004 PURPOSE To determine potential anti-proliferative properties…
Read MoreEnhanced isolation of low frequency herpes simplex virus recombinants using green-fluorescent protein and FACS.
Dec 06 2003
PubMed ID: 14656463 Author(s): Kolb AW, Brandt CR. Enhanced isolation of low frequency herpes simplex virus recombinants using green-fluorescent protein and FACS. J Virol Methods. 2004 Jan;115(1):73-81. Journal: Journal Of Virological Methods, Volume 115, Issue…
Read MoreTyrosine 116 of the herpes simplex virus type 1 IEalpha22 protein is an ocular virulence determinant and potential phosphorylation site.
Nov 01 2003
PubMed ID: 14578374 Author(s): Brandt CR, Kolb AW. Tyrosine 116 of the herpes simplex virus type 1 IEalpha22 protein is an ocular virulence determinant and potential phosphorylation site. Invest Ophthalmol Vis Sci. 2003 Nov;44(11):4601-7. PMID…
Read MoreRapid in vivo isolation of gene expression elements using an HSV amplicon system.
Oct 01 2003
PubMed ID: 14500121 Author(s): Huang CY, Brandt CR. Rapid in vivo isolation of gene expression elements using an HSV amplicon system. J Virol Methods. 2003 Oct;113(1):1-12. PMID 14500121 Journal: Journal Of Virological Methods, Volume 113,…
Read MoreLow dose latrunculin-A inhibits dexamethasone-induced changes in the actin cytoskeleton and alters extracellular matrix protein expression in cultured human trabecular meshwork cells.
Aug 01 2003
PubMed ID: 12873448 Author(s): Liu X, Wu Z, Sheibani N, Brandt CR, Polansky JR, Kaufman PL. Low dose latrunculin-A inhibits dexamethasone-induced changes in the actin cytoskeleton and alters extracellular matrix protein expression in cultured human…
Read MoreMultiple determinants contribute to the virulence of HSV ocular and CNS infection and identification of serine 34 of the US1 gene as an ocular disease determinant.
May 27 2003
PubMed ID: 12766070 Author(s): Brandt CR, Kolb AW, Shah DD, Pumfery AM, Kintner RL, Jaehnig E, Van Gompel JJ. Multiple determinants contribute to the virulence of HSV ocular and CNS infection and identification of serine…
Read MoreTransformation of human trabecular meshwork cells with SV40 TAg alters promoter utilization.
Dec 01 2002
PubMed ID: 12789541 Author(s): Liu X, Huang CY, Cai S, Polansky JR, Kaufman PL, Brandt CR. Transformation of human trabecular meshwork cells with SV40 TAg alters promoter utilization. Curr Eye Res. 2002 Dec;25(6):347-53. PMID 12789541…
Read MoreHSV-1 amplicon peptide display vector.
Nov 26 2002
PubMed ID: 12445940 Author(s): Spear MA, Schuback D, Miyata K, Grandi P, Sun F, Yoo L, Nguyen A, Brandt CR, Breakefield XO. HSV-1 amplicon peptide display vector. J Virol Methods. 2003 Jan;107(1):71-9. Journal: Journal Of…
Read MorePeptides containing membrane-transiting motifs inhibit virus entry.
Sep 27 2002
PubMed ID: 12130644 Author(s): Bultmann H, Brandt CR. Peptides containing membrane-transiting motifs inhibit virus entry. J Biol Chem. 2002 Sep 27;277(39):36018-23. Epub 2002 Jul 18. PMID 12130644 Journal: The Journal Of Biological Chemistry, Volume 277,…
Read MoreGene therapy for glaucoma: treating a multifaceted, chronic disease.
Jul 31 2002
PubMed ID: 12147578 Author(s): Borrás T, Brandt CR, Nickells R, Ritch R. Gene therapy for glaucoma: treating a multifaceted, chronic disease. Invest Ophthalmol Vis Sci. 2002 Aug;43(8):2513-8. Review. Journal: Investigative Ophthalmology & Visual Science, Volume…
Read MoreMutation of the herpes simplex virus 1 KOS UL45 gene reveals dose dependent effects on central nervous system growth.
Apr 18 2002
PubMed ID: 11958453 Author(s): Visalli RJ, Brandt CR. Mutation of the herpes simplex virus 1 KOS UL45 gene reveals dose dependent effects on central nervous system growth. Arch Virol. 2002 Mar;147(3):519-32. Journal: Archives Of Virology,…
Read MoreIn vitro localization of TIGR/MYOC in trabecular meshwork extracellular matrix and binding to fibronectin.
Jan 01 2002
PubMed ID: 11773026 Author(s): Filla MS, Liu X, Nguyen TD, Polansky JR, Brandt CR, Kaufman PL, Peters DM. In vitro localization of TIGR/MYOC in trabecular meshwork extracellular matrix and binding to fibronectin. Invest Ophthalmol Vis…
Read MoreEffect of H-7 on cultured human trabecular meshwork cells.
Jun 27 2001
PubMed ID: 11436001 Author(s): Liu X, Cai S, Glasser A, Volberg T, Polansky JR, Fauss DJ, Brandt CR, Geiger B, Kaufman PL. Effect of H-7 on cultured human trabecular meshwork cells. Mol Vis. 2001 Jun…
Read MoreHSV-1 vector-delivered FGF2 to the retina is neuroprotective but does not preserve functional responses.
May 01 2001
PubMed ID: 11356079 Author(s): Spencer B, Agarwala S, Gentry L, Brandt CR. HSV-1 vector-delivered FGF2 to the retina is neuroprotective but does not preserve functional responses. Mol Ther. 2001 May;3(5 Pt 1):746-56. PMID 11356079 Journal:…
Read MoreModified FGF4 signal peptide inhibits entry of herpes simplex virus type 1.
Mar 01 2001
PubMed ID: 11222686 Author(s): Bultmann H, Busse JS, Brandt CR. Modified FGF4 signal peptide inhibits entry of herpes simplex virus type 1. J Virol. 2001 Mar;75(6):2634-45. PMID 11222686 Journal: Journal Of Virology, Volume 75, Issue…
Read MoreHerpes simplex virus-mediated gene delivery to the rodent visual system.
May 01 2000
PubMed ID: 10798655 Author(s): Spencer B, Agarwala S, Miskulin M, Smith M, Brandt CR. Herpes simplex virus-mediated gene delivery to the rodent visual system. Invest Ophthalmol Vis Sci. 2000 May;41(6):1392-401. PMID 10798655 Journal: Investigative Ophthalmology…
Read MoreIsolation and partial characterization of an antiviral, RC-183, from the edible mushroom Rozites caperata.
Oct 12 1999
PubMed ID: 10517309 Author(s): Piraino F, Brandt CR. Isolation and partial characterization of an antiviral, RC-183, from the edible mushroom Rozites caperata. Antiviral Res. 1999 Sep;43(2):67-78. Journal: Antiviral Research, Volume 43, Issue 2, Sep 1999…
Read MoreHerpes simplex virus mediated gene transfer to primate ocular tissues.
Oct 01 1999
PubMed ID: 10504272 Author(s): Liu X, Brandt CR, Gabelt BT, Bryar PJ, Smith ME, Kaufman PL. Herpes simplex virus mediated gene transfer to primate ocular tissues. Exp Eye Res. 1999 Oct;69(4):385-95. PMID 10504272 Journal: Experimental…
Read More1,25-Dihydroxyvitamin D3 prolongs graft survival without compromising host resistance to infection or bone mineral density.
Oct 15 1998
PubMed ID: 9798689 Author(s): Cantorna MT, Hullett DA, Redaelli C, Brandt CR, Humpal-Winter J, Sollinger HW, Deluca HF. 1,25-Dihydroxyvitamin D3 prolongs graft survival without compromising host resistance to infection or bone mineral density. Transplantation. 1998…
Read MoreTreatment of spontaneously arising retinoblastoma tumors in transgenic mice with an attenuated herpes simplex virus mutant.
Mar 03 1997
PubMed ID: 9123872 Author(s): Brandt CR, Imesch PD, Robinson NL, Syed NA, Untawale S, Darjatmoko SR, Chappell RJ, Heinzelman P, Albert DM. Treatment of spontaneously arising retinoblastoma tumors in transgenic mice with an attenuated herpes…
Read MoreBarrier and antiviral effect of a new cream formulation.
Mar 01 1997
PubMed ID: 9090539 Author(s): Spencer B, Brandt CR. Barrier and antiviral effect of a new cream formulation. Infect Control Hosp Epidemiol. 1997 Mar;18(3):159-60. Journal: Infection Control And Hospital Epidemiology, Volume 18, Issue 3, Mar 1997
Read MoreThe herpes simplex virus type 1 ribonucleotide reductase is required for acute retinal disease.
Jan 01 1997
PubMed ID: 9191855 Author(s): Brandt CR, Imesch P, Spencer B, Eliassi-Rad B, Syed NA, Untawale S, Robinson NL, Albert DM. The herpes simplex virus type 1 ribonucleotide reductase is required for acute retinal disease. Arch…
Read MoreMaturation of collagen fibrils in the corneal stroma results in masking of tyrosine-rich region of type V procollagen.
Sep 01 1996
PubMed ID: 8814144 Author(s): Peters DM, Kintner RL, Steger C, Bultmann K, Brandt CR. Maturation of collagen fibrils in the corneal stroma results in masking of tyrosine-rich region of type V procollagen. Invest Ophthalmol Vis…
Read MoreEvaluation of a peptidomimetic ribonucleotide reductase inhibitor with a murine model of herpes simplex virus type 1 ocular disease.
May 01 1996
PubMed ID: 8723444 Author(s): Brandt CR, Spencer B, Imesch P, Garneau M, Déziel R. Evaluation of a peptidomimetic ribonucleotide reductase inhibitor with a murine model of herpes simplex virus type 1 ocular disease. Antimicrob Agents…
Read MoreThymidine kinase and susceptibility to interferon are not involved in the increased virulence of recombinant viruses isolated following mixed ocular infection with HSV strains OD4 and CJ394.
Jan 01 1996
PubMed ID: 8792363 Author(s): Pumfery AM, Brandt CR. Thymidine kinase and susceptibility to interferon are not involved in the increased virulence of recombinant viruses isolated following mixed ocular infection with HSV strains OD4 and CJ394.…
Read MoreEvidence for an interaction of herpes simplex virus with chondroitin sulfate proteoglycans during infection.
Apr 20 1995
PubMed ID: 7747425 Author(s): Banfield BW, Leduc Y, Esford L, Visalli RJ, Brandt CR, Tufaro F. Evidence for an interaction of herpes simplex virus with chondroitin sulfate proteoglycans during infection. Virology. 1995 Apr 20;208(2):531-9. Journal:…
Read MoreIFN-alpha induces MxA gene expression in cultured human corneal fibroblasts.
Feb 01 1995
PubMed ID: 7540146 Author(s): Abrams ME, Balish MJ, Brandt CR. IFN-alpha induces MxA gene expression in cultured human corneal fibroblasts. Exp Eye Res. 1995 Feb;60(2):137-42. Journal: Experimental Eye Research, Volume 60, Issue 2, Feb 1995…
Read MoreThe effect of viral inoculum level and host age on disease incidence, disease severity, and mortality in a murine model of ocular HSV-1 infection.
Feb 01 1995
PubMed ID: 7768106 Author(s): Kintner RL, Brandt CR. The effect of viral inoculum level and host age on disease incidence, disease severity, and mortality in a murine model of ocular HSV-1 infection. Curr Eye Res.…
Read MoreRecombinants are isolated at high frequency following in vivo mixed ocular infection with two avirulent herpes simplex virus type 1 strains.
Jan 01 1995
PubMed ID: 7710352 Author(s): Kintner RL, Allan RW, Brandt CR. Recombinants are isolated at high frequency following in vivo mixed ocular infection with two avirulent herpes simplex virus type 1 strains. Arch Virol. 1995;140(2):231-44. PMID…
Read MoreRenin mRNA is synthesized locally in rat ocular tissues.
Oct 01 1994
PubMed ID: 7531130 Author(s): Brandt CR, Pumfery AM, Micales B, Bindley CD, Lyons GE, Sramek SJ, Wallow IH. Renin mRNA is synthesized locally in rat ocular tissues. Curr Eye Res. 1994 Oct;13(10):755-63. PMID 7531130 Journal:…
Read MoreRapid small-scale isolation of herpes simplex virus DNA.
Jul 01 1994
PubMed ID: 7989436 Author(s): Kintner RL, Brandt CR. Rapid small-scale isolation of Herpes simplex virus DNA. J Virol Methods. 1994 Jul;48(2-3):189-96. PMID 7989436 Journal: Journal Of Virological Methods, Volume 48, Issue 2 3, Jul 1994…
Read MoreGlycoprotein C-independent binding of herpes simplex virus to cells requires cell surface heparan sulphate and glycoprotein B.
Jun 01 1994
PubMed ID: 8207388 Author(s): Herold BC, Visalli RJ, Susmarski N, Brandt CR, Spear PG. Glycoprotein C-independent binding of herpes simplex virus to cells requires cell surface heparan sulphate and glycoprotein B. J Gen Virol. 1994…
Read MoreInterferon-alpha and interferon-gamma induced modulation of proteins in human corneal fibroblasts.
Aug 01 1993
PubMed ID: 8228389 Author(s): Balish MJ, Abrams ME, Chandler JW, Brandt CR. Interferon-alpha and interferon-gamma induced modulation of proteins in human corneal fibroblasts. J Interferon Res. 1993 Aug;13(4):289-94. PMID 8228389 Journal: Journal Of Interferon Research,…
Read MoreThe HSV-1 UL45 18 kDa gene product is a true late protein and a component of the virion.
Aug 01 1993
PubMed ID: 8212858 Author(s): Visalli RJ, Brandt CR. The HSV-1 UL45 18 kDa gene product is a true late protein and a component of the virion. Virus Res. 1993 Aug;29(2):167-78. PMID 8212858 Journal: Virus Research,…
Read MoreIFN-gamma-mediated antimicrobial response. Indoleamine 2,3-dioxygenase-deficient mutant host cells no longer inhibit intracellular Chlamydia spp. or Toxoplasma growth.
Jun 15 1993
PubMed ID: 8515074 Author(s): Thomas SM, Garrity LF, Brandt CR, Schobert CS, Feng GS, Taylor MW, Carlin JM, Byrne GI. IFN-gamma-mediated antimicrobial response. Indoleamine 2,3-dioxygenase-deficient mutant host cells no longer inhibit intracellular Chlamydia spp. or…
Read MoreHeterogeneity of type I collagen expression in human corneal keratoconus fibroblasts.
Jan 01 1993
PubMed ID: 7505054 Author(s): Peters DP, Harrison DA, Brandt CR. Heterogeneity of type I collagen expression in human corneal keratoconus fibroblasts. Ophthalmic Res. 1993;25(5):273-9. PMID 7505054 Journal: Ophthalmic Research, Volume 25, Issue 5, 1993 Corneal…
Read MoreEnhanced inhibition of herpes simplex virus type 1 growth in human corneal fibroblasts by combinations of interferon-alpha and -gamma.
Dec 01 1992
PubMed ID: 1331251 Author(s): Balish MJ, Abrams ME, Pumfery AM, Brandt CR. Enhanced inhibition of herpes simplex virus type 1 growth in human corneal fibroblasts by combinations of interferon-alpha and -gamma. J Infect Dis. 1992…
Read MoreAn ocular renin-angiotensin system. Immunohistochemistry of angiotensinogen.
Apr 01 1992
PubMed ID: 1559760 Author(s): Sramek SJ, Wallow IH, Tewksbury DA, Brandt CR, Poulsen GL. An ocular renin-angiotensin system. Immunohistochemistry of angiotensinogen. Invest Ophthalmol Vis Sci. 1992 Apr;33(5):1627-32. PMID 1559760 Journal: Investigative Ophthalmology & Visual Science,…
Read MoreA murine model of herpes simplex virus-induced ocular disease for antiviral drug testing.
Mar 01 1992
PubMed ID: 1560105 Author(s): Brandt CR, Coakley LM, Grau DR. A murine model of herpes simplex virus-induced ocular disease for antiviral drug testing. J Virol Methods. 1992 Mar;36(3):209-22. PMID 1560105 Journal: Journal Of Virological Methods,…
Read MoreActivation of NK cells in mice following corneal infection with herpes simplex virus type-1.
Jan 01 1992
PubMed ID: 1370438 Author(s): Brandt CR, Salkowski CA. Activation of NK cells in mice following corneal infection with herpes simplex virus type-1. Invest Ophthalmol Vis Sci. 1992 Jan;33(1):113-20. PMID 1370438 Journal: Investigative Ophthalmology & Visual…
Read MoreSusceptibility of +/+, +/nu and nu/nu BALB/c mice to ocular herpes simplex virus infection.
Jan 01 1992
PubMed ID: 1287512 Author(s): Brandt CR. Susceptibility of +/+, +/nu and nu/nu BALB/c mice to ocular herpes simplex virus infection. Ophthalmic Res. 1992;24(6):332-7. PMID 1287512 Journal: Ophthalmic Research, Volume 24, Issue 6, 1992 Athymic (nude)…
Read MoreThe HSV-1 UL45 gene product is not required for growth in Vero cells.
Nov 01 1991
PubMed ID: 1656593 Author(s): Visalli RJ, Brandt CR. The HSV-1 UL45 gene product is not required for growth in Vero cells. Virology. 1991 Nov;185(1):419-23. Journal: Virology, Volume 185, Issue 1, Nov 1991 We have constructed…
Read MoreMixed ocular infections identify strains of herpes simplex virus for use in genetic studies.
Nov 01 1991
PubMed ID: 1667784 Author(s): Brandt CR. Mixed ocular infections identify strains of herpes simplex virus for use in genetic studies. J Virol Methods. 1991 Nov-Dec;35(2):127-35. PMID 1667784 Journal: Journal Of Virological Methods, Volume 35, Issue…
Read MoreThe herpes simplex virus ribonucleotide reductase is required for ocular virulence.
Sep 01 1991
PubMed ID: 1654368 Author(s): Brandt CR, Kintner RL, Pumfery AM, Visalli RJ, Grau DR. The herpes simplex virus ribonucleotide reductase is required for ocular virulence. J Gen Virol. 1991 Sep;72 ( Pt 9):2043-9. PMID 1654368…
Read MoreIn vivo induction of Ia expression in murine cornea after intravitreal injection of interferon-gamma.
Nov 01 1990
PubMed ID: 2122962 Author(s): Brandt CR, Knupfer PB, Boush GA, Gausas RE, Chandler JW. In vivo induction of Ia expression in murine cornea after intravitreal injection of interferon-gamma. Invest Ophthalmol Vis Sci. 1990 Nov;31(11):2248-53. PMID…
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